Guenter Grethe obtained his Ph.D. from the Technical University of Braunschweig in 1961 with a thesis on the total synthesis of tetracycline antibiotics with Professor H. Muxfeldt. In 1963 he joined Hoffmann-LaRoche, Nutley, NJ, as a Research Chemist. His work on the totalsynthesis of natural products resulted in over twenty patents. A one-year sabbatical in 1972 at Princeton University with Todd Wipke introduced him to the use of computers in chemistry, specifically in synthesis planning. After 22 years with Roche he joined MDL Information Systems, Inc. in 1985 until his retirement in 2003. He is now consulting for FIZ Chemie Berlin and InfoChem Munich. Guenter’s main interests are in the area of reaction databases and reaction data management software and applications. Integration of data and user-friendly access has played a significant role in his work. Guenter has published extensively and has given presentations and organized symposia at national and international scientific meetings, including Pacifichem, on topics in synthetic chemistry and in the area of reaction data management. He was chairman of the International Conference on Chemical Structures in 1996, 1999 and 2002 and a regional organizer for Pacifichem in 2005. He is a member of the American Chemical Society (ACS) and the Gesellschaft Deutscher Chemiker (GDCh). He held several positions in the ACS Division of Chemical Information (CINF), including Division and Program Chair. He was Secretary General of the Biotechnology Secretariat from 2000 through 2003. In 2005 he initiated the first international interdivisional collaboration between the Chemistry-Computer-Information Fachgruppe (CIC) of the German Chemical Society and the Division of Chemical Information of the American Chemical Society. As a member of the Steering Committee of the Multidisciplinary Program Planning Group (MPPG) of ACS he is chairing the subcommittee on Thematic Programming. In 2001 he received the Herman Skolnik Award of the Division of Chemical Information of the American Chemical Society for outstanding contributions in the field of chemical information. In recognition of his many activities, the CINF Division presented him with the Meritorious Service Award in 2004. From 2000 – 2005 he was Chairman of the Chemical Structure Association Trust and in 2005 was awarded the CSA Trust Ernie Hyde Award.