Dr Jonathan Goodman is a Professor in the Department of Chemistry at the University of Cambridge, Deputy-Director of the Unilever Centre for Molecular Science Informatics, and a Fellow of Clare College. He did his PhD at Cambridge with Professor Ian Paterson FRS using experimental and computational methods to study the aldol reaction. He then worked with Professor Clark Still at Columbia University developing the Macromodel molecular mechanics program and studying molecular recognition. His current research interests cover experimental organic chemistry, molecular modelling and chemical informatics. His research has lead to about a hundred publications and a book in these areas. Experimentally, recent work has included the development of asymmetric epoxidation reagents, and the investigation of solubility properties of drug-like compounds. Within chemical informatics, he set up one of the world’s first chemistry WWW servers, and develops databases and resources that are used around the world. His computational studies of molecular structure and reactivity have lead to widely used methods of conformational analysis and to the solution of puzzling aspects of organic reactivity.